Continuous variable controlled quantum dialogue and secure multiparty quantum computation

A continuous variable controlled quantum dialogue scheme is proposed. The scheme is further modified to obtain two other protocols of continuous variable secure multiparty computation. The first one of these protocols provides a solution of two party socialist millionaire problem, while the second protocol provides a solution for a special type of multi-party socialist millionaire problem which can be viewed as a protocol for multiparty quantum private comparison. It is shown that the proposed scheme of continuous variable controlled quantum dialogue can be performed using bipartite entanglement and can be reduced to obtain several other two and three party cryptographic schemes in the limiting cases. The security of the proposed scheme and its advantage over corresponding discrete variable counterpart are also discussed. Specifically, the ignorance of an eavesdropper in the proposed scheme is shown to be very high compared with corresponding discrete variable scheme and thus the present scheme is less prone to information leakage inherent with the discrete variable quantum dialogue based schemes.It is further established that the proposed scheme can be viewed as a continuous variable counterpart of quantum cryptographic switch which allows a supervisor to control the information transferred between the two legitimate parties to a continuously varying degree.Comment: Quantum dialogue and its application in the continuous variable scenario is studied in detai

Optimal Pattern Synthesis of Linear Antenna Array Using Grey Wolf Optimization Algorithm

The aim of this paper is to introduce the grey wolf optimization (GWO) algorithm to the electromagnetics and antenna community. GWO is a new nature-inspired metaheuristic algorithm inspired by the social hierarchy and hunting behavior of grey wolves. It has potential to exhibit high performance in solving not only unconstrained but also constrained optimization problems. In this work, GWO has been applied to linear antenna arrays for optimal pattern synthesis in the following ways: by optimizing the antenna positions while assuming uniform excitation and by optimizing the antenna current amplitudes while assuming spacing and phase as that of uniform array. GWO is used to achieve an array pattern with minimum side lobe level (SLL) along with null placement in the specified directions. GWO is also applied for the minimization of the first side lobe nearest to the main beam (near side lobe). Various examples are presented that illustrate the application of GWO for linear array optimization and, subsequently, the results are validated by benchmarking with results obtained using other state-of-the-art nature-inspired evolutionary algorithms. The results suggest that optimization of linear antenna arrays using GWO provides considerable enhancements compared to the uniform array and the synthesis obtained from other optimization techniques

A hybrid scheme for prime factorization and its experimental implementation using IBM quantum processor

We report a quantum-classical hybrid scheme for factorization of bi-prime numbers (which are odd and square-free) using IBM's quantum processors. The hybrid scheme proposed here involves both classical optimization techniques and adiabatic quantum optimization techniques, and is build by extending a previous scheme of hybrid factorization [Pal et al., Pramana 92, 26 (2019) and Xu et al., Phys. Rev. Lett. 108, 130501 (2012)]. The quantum part of the scheme is very general in the sense that it can be implemented using any quantum computing architecture. Here, as an example, we experimentally implement our scheme for prime factorization using IBM's QX4 quantum processor and have factorised 35.Comment: 8 pages, 4 figures, 2 table

Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018

Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here we present a geospatial analysis of EBF prevalence estimates from 2000 to 2018 across 94 LMICs mapped to policy-relevant administrative units (for example, districts), quantify subnational inequalities and their changes over time, and estimate probabilities of meeting the World Health Organization’s Global Nutrition Target (WHO GNT) of ≥70% EBF prevalence by 2030. While six LMICs are projected to meet the WHO GNT of ≥70% EBF prevalence at a national scale, only three are predicted to meet the target in all their district-level units by 2030

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Tissue engineering bone using autologous progenitor cells in the peritoneum.

Despite intensive research efforts, there remains a need for novel methods to improve the ossification of scaffolds for bone tissue engineering. Based on a common phenomenon and known pathological conditions of peritoneal membrane ossification following peritoneal dialysis, we have explored the possibility of regenerating ossified tissue in the peritoneum. Interestingly, in addition to inflammatory cells, we discovered a large number of multipotent mesenchymal stem cells (MSCs) in the peritoneal lavage fluid from mice with peritoneal catheter implants. The osteogenic potential of these peritoneal progenitor cells was demonstrated by their ability to easily infiltrate decalcified bone implants, produce osteocalcin and form mineralized bone in 8 weeks. Additionally, when poly(l-lactic acid) scaffolds loaded with bone morphogenetic protein-2 (a known osteogenic differentiation agent) were implanted into the peritoneum, signs of osteogenesis were seen within 8 weeks of implantation. The results of this investigation support the concept that scaffolds containing BMP-2 can stimulate the formation of bone in the peritoneum via directed autologous stem and progenitor cell responses

Gelucire Based In Situ Gelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs

Non steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications to the geriatric patients for the treatment of arthritis and other painful disorders. The major side effects of NSAIDs are related to their effects on the stomach and bowels. The present study concerns assessment of the potential of liquid in situ gelling emulsion formulations (emulgels) as patient compliant stomach specific sustained release carrier for the delivery of highly gastric irritant drug, Piroxicam. Emulgels were prepared, without using any emulgent, by mixing different concentrations of molten Gelucire 39/01 with low viscosity sodium alginate solution prepared in deionized water at 50°C. CaCO3 was used as buoyancy imparting as well as crosslinking agent. Emulgels so prepared were homogenous, physically stable, and rapidly formed into buoyant gelled mass when exposed to simulated gastric fluid (SGF, pH 1.2). Drug release studies carried out in SGF revealed significant retardation (P<0.05) of Piroxicam release from emulgels compared to conventional in situ gelling formulations prepared without Gelucire 39/01. Pharmacodynamic studies carried out in albino rats revealed significantly increased analgesic/anti-inflammatory response from in situ emulgels compared to conventional in situ gelling formulations. Further, in vivo toxicity studies carried out in albino rats revealed no signs of gastric ulceration upon prolonged dosing

A sphenoid sinus mucocele simulating as retro bulbar optic neuritis

A 25-year-old male presented with complaints of sudden diminution of vision with pain on eye movement in the left eye which was diagnosed clinically as retro bulbar optic neuritis. However, magnetic resonance imaging (MRI) showed lesion consistent with sphenoid sinus mucocele. Early surgical removal of mucocele led to complete recovery of vision, contrast and visual field. A high index of suspicion is necessary for intracranial lesions in all cases of retro bulbar neuritis, especially those with atypical symptoms